Pick's disease is a rare, chronic and progressive CNS disease characterized by atrophy of the temporal, as well as frontal lobes of the cerebral cortex with an increase in dementia. The disease begins in 50-60 years, although there are later or earlier manifestations. Women tend to get sick more often than men.
A. Peak in 1892 gave a description of cases of senile dementia, aggravated by the atrophic process mainly in the temporal and frontal lobes. Similar studies were conducted by A. Alzheimer, X. Lipman, E. Altman. Statements that the cases of the disease described by A. Pick represent an independent form were first noted by X. Richter. The confirmation of this nosological independence of the disease was the pathological studies that showed a number of morphological features of this particular pathology.
Morphological features include the following signs: the limited nature of atrophic changes in the frontal and temporal lobes; insignificant degree or absence of vascular changes; loss of elements of the nervous tissue in the upper layers of the cortex gol. brain; the absence of all signs of the inflammatory process, as well as senile plaques or alzheimer's changes in neurofibrils; atrophic changes, passing into the subcortical region; the frequent presence of spherical argentophilic intracellular formations, as well as swollen cells.
The atrophic process is unevenly distributed in some parts of the brain, starting in typical areas called wrinkling and atrophy centers.